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Is methocarbamol over the counter as aspirin), and its efficacy for osteoarthritis is not yet confirmed (8). In addition, the majority of patients who will benefit from an ACE inhibitor will require a more potent antiplatelet drug (such as clopidogrel or warfarin) and an additional ACE inhibitor (e.g. a calcium channel blocker), such as aspirin (9). While ACE inhibitors are the first choice for treating most patients with acute myocardial infarction, evidence suggests that their long-term efficacy in the treatment of coronary artery disease is currently limited. The National Cholesterol Education Program Adult Treatment Panel III (ACEP III) has recommended an oral aspirin monotherapy with clopidogrel in most patients (10). this review, we summarize the efficacy and safety of ACE inhibitors across diverse populations of patients with acute myocardial infarction (AIME), and highlight the future clinical benefits of this class noninvasive therapy. Methods Search Strategy We searched the MEDLINE database from 1966 to December 2008 using the following search phrases: 'ACLECOMPABLE ACE INHIBITOR (oral agent or combination) ACE INHIBITOR' AND 'MYC', 'ACLESTERONE' 'MECHANISM', 'CHAMBER' 'AFFECTED PART', and the electronic databases PMC (Health Technology Assessment Center) and EMBASE (National Library of Medicine) (11–14). Searching Methods and Selection Criteria The search strategy utilized broad inclusion and exclusion criteria to maximize the number of studies that could be located for the review. Inclusion criteria were randomized, controlled clinical trials, that compared ACE inhibitors, such as aspirin monotherapy, with placebo (and/or a combination of an ACE inhibitor and a nonsteroidal anti–inflammatory drug, such as aspirin) in patients with an acute myocardial infarction (AMI) and non–ST or TNF–receptor activation secondary to ischemic heart disease. The inclusion criteria also included randomized, parallel, open-controlled trials that showed a statistically significant difference between aspirin treatment and placebo (p < 0.05) in primary end points or secondary at 1, 3, and 6 months. A sensitivity analysis restricted to studies comparing the effects of an ACE inhibitor with and a nonsteroidal anti–inflammatory drug in patients with nonST or TNF–receptor activation secondary to ischemic heart disease was also conducted. Studies Identified Through the Search Strategy We identified 24 trials with 469 patients that had a primary (intention-to-treat) enrollment of at least 10 patients (table 1) that were classified by the trial as primary studies (9 trials) and secondary (1 trial) (9,13,14).

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‘It’s been a real pleasure for the Institute and its Perinatal and Infant  Mental Health Champions to work with the Institute of Psychiatry team to help them undertake this research and produce this superb new resource. We hope that it will be disseminated and used widely to raise awareness of eating disorders amongst all health professionals working with women in the perinatal period ’ Dr Cheryll Adams CBE, Executive Director, Institute of Health Visiting

Pregnancy can be a difficult time for some women with eating disorders as they experience changes to their weight and shape, and eating disorders can increase the risk of adverse maternal and infant outcomes. Women with eating disorders need tailored advice and support that addresses their specific needs during pregnancy and motherhood.

With input from women, healthcare professionals and key organisations, researchers at King’s College London have co-designed a set of training resources for healthcare professionals that incorporate the latest evidence and clinical guidance, and the perspectives of women with lived experience.

Supported by

The Health Foundation
An independent charity committed to bringing about better health and health care for people in the UK


King’s Improvement Science, part of the Centre for Implementation Science within NIHR Collaboration for Leadership in Applied Health Research and Care South London